Recent papers published from our lab

Loss of a mammalian circular RNA locus causes miRNA deregulation and affects brain function.
Piwecka M, Glažar P, Hernandez-Miranda LR, Memczak S, Wolf SA, Rybak-Wolf A, Filipchyk A, Klironomos F, Cerda Jara CA, Fenske P, Trimbuch T, Zywitza V, Plass M, Schreyer L, Ayoub S, Kocks C, Kühn R, Rosenmund C, Birchmeier C, Rajewsky N.
Science. 2017 Aug 10. pii: eaam8526. doi: 10.1126/science.aam8526.


Heterodimerization of Munc13 C2A domain with RIM regulates synaptic vesicle docking and priming.
Camacho M, Basu J, Trimbuch T, Chang S, Pulido-Lozano C, Chang SS, Duluvova I, Abo-Rady M, Rizo J, Rosenmund C.
Nat Commun. 2017 May 10;8:15293. doi: 10.1038/ncomms15293.


Characterization of a Human Point Mutation of VGLUT3 (p.A211V) in the Rodent Brain Suggests a Nonuniform Distribution of the Transporter in Synaptic Vesicles.
Ramet L, Zimmermann J, Bersot T, Poirel O, De Gois S, Silm K, Sakae DY, Mansouri-Guilani N, Bourque MJ, Trudeau LE, Pietrancosta N, Daumas S, Bernard V, Rosenmund C, El Mestikawy S.
J Neurosci. 2017 Apr 12;37(15):4181-4199. doi: 10.1523/JNEUROSCI.0282-16.2017. Epub 2017 Mar 17.


ELKS1 localizes the synaptic vesicle priming protein bMunc13-2 to a specific subset of active zones.
Kawabe H, Mitkovski M, Kaeser PS, Hirrlinger J, Opazo F, Nestvogel D, Kalla S, Fejtova A, Verrier SE, Bungers SR, Cooper BH, Varoqueaux F, Wang Y, Nehring RB, Gundelfinger ED, Rosenmund C, Rizzoli SO, Südhof TC, Rhee JS, Brose N.
J Cell Biol. 2017 Apr 3;216(4):1143-1161. doi: 10.1083/jcb.201606086. Epub 2017 Mar 6. Erratum in: J Cell Biol. 2017


Mechanistic insights into neurotransmitter release and presynaptic plasticity from the crystal structure of Munc13-1 C1C2BMUN.
Xu J, Camacho M, Xu Y, Esser V, Liu X, Trimbuch T, Pan YZ, Ma C, Tomchick DR, Rosenmund C, Rizo J.
Elife. 2017 Feb 8;6. pii: e22567. doi: 10.7554/eLife.22567.


Loss of MeCP2 disrupts cell autonomous and autocrine BDNF signaling in mouse glutamatergic neurons.
Sampathkumar C, Wu YJ, Vadhvani M, Trimbuch T, Eickholt B, Rosenmund C.
Elife. 2016 Oct 26;5. pii: e19374. doi: 10.7554/eLife.19374.


RIM-binding protein 2 regulates release probability by fine-tuning calcium channel localization at murine hippocampal synapses.
Grauel MK, Maglione M, Reddy-Alla S, Willmes CG, Brockmann MM, Trimbuch T, Rosenmund T, Pangalos M, Vardar G, Stumpf A, Walter AM, Rost BR, Eickholt BJ, Haucke V, Schmitz D, Sigrist SJ, Rosenmund C.
Proc Natl Acad Sci U S A. 2016 Oct 11;113(41):11615-11620. Epub 2016 Sep 26.


Distinct Functions of Syntaxin-1 in Neuronal Maintenance, Synaptic Vesicle Docking, and Fusion in Mouse Neurons.
Vardar G, Chang S, Arancillo M, Wu YJ, Trimbuch T, Rosenmund C.
J Neurosci. 2016 Jul 27;36(30):7911-24. doi: 10.1523


Functional Synergy between the Munc13 C-terminal C1 and C2 domains.
Liu X, Seven AB, Camacho M, Esser V, Xu J, Trimbuch T, Quade B, Su L, Ma C, Rosenmund C, Rizo J.
eLife 2016;10.7554/eLife.13696


Catching Up with Ultrafast Endocytosis
Brockmann MM, Rosenmund C.
Neuron. 2016 May 4;90(3):423-4. doi: 10.1016


Should I stop or should I go? The role of complexin in neurotransmitter release.
Trimbuch T, Rosenmund C.
Nature Reviews Neuroscience  17, 118–125 (2016)


Optogenetic acidification of synaptic vesicles and lysosomes.
Rost BR, Schneider F, Grauel MK, Wozny C, G Bentz C, Blessing A, Rosenmund T, Jentsch TJ, Schmitz D, Hegemann P, Rosenmund C.
Nat Neurosci. 2015 Nov 9. doi: 10.1038/nn.4161.


Co-release of glutamate and GABA from single vesicles in GABAergic neurons exogenously expressing VGLUT3.
Zimmermann J, Herman MA, Rosenmund C.
Front Synaptic Neurosci. 2015 Sep 23;7:16


Syntaxin 1B is important for mouse postnatal survival and proper synaptic function at the mouse neuromuscular junctions.
Wu Y-J, Tejero R, Arancillo M, Vardar G, Korotkova T, Kintscher M, Schmitz D, Ponomarenko A, Tabares L, Rosenmund C.
Journal of Neurophysiology Published 1 October 2015 Vol. 114 no. 4, 2404-2417 DOI: 10.1152/jn.00577.2015


Ligand-dependent opening of the multiple AMPA receptor conductance states: a concerted model.
Dutta-Roy R, Rosenmund C, Edelstein SJ, Le Novère N.
PLoS One. 2015 Jan 28;10(1):e0116616. doi: 10.1371/journal.pone.0116616.


On the Brink: A New Synaptic Vesicle Release Model at the Calyx of Held.
Herman MA, Rosenmund C.
Neuron. 2015 Jan 7;85(1):6–8


Clathrin regenerates synaptic vesicles from endosomes.
Watanabe S, Trimbuch T, Camacho-Pérez M, Rost BR, Brokowski B, Söhl-Kielczynski B, Felies A, Davis MW, Rosenmund C, Jorgensen EM.
Nature. 2014 Nov 13;515(7526):228-33


The morphological and molecular nature of synaptic vesicle priming at presynaptic active zones.
Imig C, Min SW, Krinner S, Arancillo M, Rosenmund C, Südhof TC, Rhee J, Brose N, Cooper BH.
Neuron. 2014 Oct 22;84(2):416-31


Synaptobrevin 1 mediates vesicle priming and evoked release in a subpopulation of hippocampal neurons.
Zimmermann J, Trimbuch T, Rosenmund C.
J Neurophysiol. 2014 Sep 15;112(6):1559-65.


Vesicular glutamate transporter expression level affects synaptic vesicle release probability at hippocampal synapses in culture.
Herman MA, Ackermann F, Trimbuch T, Rosenmund C.
J Neurosci. 2014 Aug 27;34(35):11781-91.


Biophysical properties of presynaptic short-term plasticity in hippocampal neurons: insights from electrophysiology, imaging and mechanistic models.
Dutta Roy R, Stefan MI, Rosenmund C.
Front Cell Neurosci. 2014 May 22;8:141


Re-examining how complexin inhibits neurotransmitter release: SNARE complex insertion or electrostatic hindrance?
Trimbuch T, Xu J, Flaherty D, Tomchick DR, Rizo J, Rosenmund C.
eLife 2014;10.7554/eLife.02391


Biophysical properties of presynaptic short-term plasticity in hippocampal neurons: insights from electrophysiology, imaging and mechanistic models.
Dutta Roy R, Stefan MI, and Rosenmund C.
Front. Cell. Neurosci. | doi: 10.3389/fncel.2014.00141 


Investigation of Synapse Formation and Function in a Glutamatergic-GABAergic Two-Neuron Microcircuit.
Chang CL, Trimbuch T, Chao HT, Jordan JC, Herman MA, Rosenmund C.
J Neurosci. 2014 Jan 15;34(3):855-68.


Nanometer-resolution fluorescence electron microscopy (nano-EM) in cultured cells.
Watanabe S, Lehmann M, Hujber E, Fetter RD, Richards J, Söhl-Kielczynski B, Felies A, Rosenmund C, Schmoranzer J, Jorgensen EM.
Methods Mol Biol. 2014;1117:503-26.


Ultrafast endocytosis at mouse hippocampal synapses.
Watanabe S, Rost BR, Camacho-Pérez M, Davis MW, Söhl-Kielczynski B, Rosenmund C, Jorgensen EM.
Nature. 2013 Dec 12;504(7479):242-7.


Titration of Syntaxin1 in mammalian synapses reveals multiple roles in vesicle docking, priming, and release probability.
Arancillo M, Min SW, Gerber S, Münster-Wandowski A, Wu YJ, Herman M, Trimbuch T, Rah JC, Ahnert-Hilger G, Riedel D, Südhof TC, Rosenmund C.
J Neurosci. 2013 Oct 16;33(42):16698-714.


Endocytosis gets in tune with action potential bursts.
Herman MA, Rosenmund C.
Elife. 2013;2:e01234. doi: 10.7554/eLife.01234.


RasGRF2 Rac-GEF activity couples NMDA receptor calcium flux to enhanced synaptic transmission.
Schwechter B, Rosenmund C, Tolias KF.
Proc Natl Acad Sci U S A. 2013 Aug 27;110(35):14462-7.


Syntaxin-1 N-peptide and Habc-domain perform distinct essential functions in synaptic vesicle fusion.
Zhou P, Pang ZP, Yang X, Zhang Y, Rosenmund C, Bacaj T, Südhof TC.
EMBO J. 2013 Jan 9;32(1):159-71.


Activation of metabotropic GABA receptors increases the energy barrier for vesicle fusion.
Rost BR, Nicholson P, Ahnert-Hilger G, Rummel A, Rosenmund C, Breustedt J, Schmitz D.
J Cell Sci. 2011 Sep 15;124(Pt 18):3066-73.


Interplay between VGLUT isoforms and endophilin A1 regulates neurotransmitter release and short-term plasticity.
Weston MC, Nehring RB, Wojcik SM, Rosenmund C.
Neuron. 2011 Mar 24;69(6):1147-59


Dysfunction in GABA signalling mediates autism-like stereotypies and Rett syndrome phenotypes.
Chao HT, Chen H, Samaco RC, Xue M, Chahrour M, Yoo J, Neul JL, Gong S, Lu HC, Heintz N, Ekker M, Rubenstein JL, Noebels JL, Rosenmund C, Zoghbi HY. 
Nature. 2010 Nov 11;468(7321):263-9.


Structural and mutational analysis of functional differentiation between synaptotagmins-1 and -7.
Xue M, Craig TK, Shin OH, Li L, Brautigam CA, Tomchick DR, Südhof TC, Rosenmund C, Rizo J. 
PLoS One. 2010 Sep 2;5(9). pii: e12544.


Binding of the complexin N terminus to the SNARE complex potentiates synaptic-vesicle fusogenicity.
Xue M, Craig TK, Xu J, Chao HT, Rizo J, Rosenmund C. 
Nat Struct Mol Biol. 2010 May;17(5):568-75.


Munc13 C2B domain is an activity-dependent Ca2+ regulator of synaptic exocytosis.
Shin OH, Lu J, Rhee JS, Tomchick DR, Pang ZP, Wojcik SM, Camacho-Perez M, Brose N, Machius M, Rizo J, Rosenmund C, Südhof TC. 
Nat Struct Mol Biol. 2010 Mar;17(3):280-8.


Tilting the balance between facilitatory and inhibitory functions of mammalian and Drosophila Complexins orchestrates synaptic vesicle exocytosis.
Xue M, Lin YQ, Pan H, Reim K, Deng H, Bellen HJ, Rosenmund C.
Neuron. 2009 Nov 12;64(3):367-80.
(Highlighted in F1000 as exceptional)


The headache of a hyperactive calcium channel.
Xue M, Rosenmund C.
Neuron. 2009 Mar 12;61(5):653-4.


Synaptic vesicle fusion.
Rizo J, Rosenmund C.
Nat Struct Mol Biol. 2008 Jul;15(7):665-74.